| Customization: | Available |
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| Type: | Cosmetic Peptide |
| Chemical Character: | Peptide |
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Products Name: Humanin
CAS No.: 330936-69-1
Purity: >99.0%
Appearance: White Lyophilized powder
Reconstitution: Required
Storage:After reconstitution store at 2°C - 8°C
Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor pathogenesis is poorly understood. Here, we evaluated the effect of HN on the progression of experimental triple negative breast cancer (TNBC).
The meta-analysis of transcriptomic data from The Cancer Genome Atlas indicated that HN and its receptors are expressed in breast cancer specimens. By immunohistochemistry we observed up-regulation of HN in TNBC biopsies when compared to mammary gland sections from healthy donors. Addition of exogenous HN protected TNBC cells from apoptotic stimuli whereas shRNA-mediated HN silencing reduced their viability and enhanced their chemo-sensitivity. Systemic administration of HN in TNBC-bearing mice reduced tumor apoptotic rate, impaired the antitumor and anti-metastatic effect of chemotherapy and stimulated tumor progression, accelerating tumor growth and development of spontaneous lung metastases. These findings suggest that HN may exert pro-tumoral effects and thus, caution should be taken when using exogenous HN to treat degenerative diseases. In addition, our study suggests that HN blockade could constitute a therapeutic strategy to improve the efficacy of chemotherapy in breast cancer.
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| Before ordering | Please send what items and what quantity you need |
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| Tracking | We will provide the tracking after goods sent. |
| Lead time | About 1-5 working days after payment |
| Shipping time | About 8-15 days door to door |
| After-sale service | Available always |
Q: How to order this product?
A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or message, and we will send you order confirmation, then you can make your order accordingly.
Q: How long can I receive my ordered goods?
A: We ship by special line shipping door to door; you can receive it in about 8-15 days.
Q: What's your MOQ?
A:For the regular produced products, our MOQ is 1box; For other customized products, our MOQ starts from 10boxes to 50boxes.
Q: Is there a discount?
A: Yes, for larger quantity order, we always support with better price.
Q: How to store it?
A: If it hasn't been opened, just put it in cool dry place, if it is opened, you may put it in cold storage for 2-5 degree condition.
Q: Are you manufacturer or trading company?
A: We are manufacturer for over 8 years now, peptides are our main product, and we are also develop others, such as raw powders, nootropics, plant extracts, etc.
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